报告题目：Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts cancer malignancy

报告人：  Dr. Xiuwei Yang, Assistant Professor

           Department of Pharmacology & Nutritional Sciences, University of Kentucky

报告时间：2017

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报告地点：正规beat365旧版_365bet开户网站_best365网页版登录附属第一医院总院（平海路899号）12楼呼吸内科示教室

Dr. Yang 简历

杨博士现任美国肯塔基大学助理教授（Tenure Track），加拿大Manitoba大学博士、美国哈佛大学Dana-Farber肿瘤研究所博士后。美国癌症研究协会会员、美国细胞生物学会会员。主要从事以乳腺癌为主的多种实体瘤的细胞与分子生物学，尤其在肿瘤转移相关基因的调控机制方面取得了突出的成绩。近年来，杨教授主持承担总额100万美金的各类课题；以通讯作者等身份在《Oncogenesis》、《Oncotarget》、《Cell Cycle》、《J Cell Sci》、《Cancer Res》、《J Cell Biol》、《Oncogene》、《Neoplasia》和《J Biol Chem》等国际权威期刊上发表论文20余篇。杨教授担任包括Intl J Cancer、Plos One等多种国际学术期刊的审稿人。

代表性论文：（*，通讯作者）

1. Bingwei Xu, Jason Lefringhouse, Zeyi Liu, Dava West, Lauren A Baldwin, Cathy Ou, Li Chen, Dana Napier, Luksana Chaiswing, LD Brewer, D St. Clair, O Thibault, JR van Nagell, BP Zhou, Ronny Drapkin, Jianan Huang*, ML Lu*, FR Ueland*, XH Yang*. Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy. Oncogenesis. 2017 Jan 30;6(1):e295.

2. Pengcheng Zhou#, Sonia Erfani#, Zeyi Liu#, Changhe Jia#, Yecang Chen#, Bingwei Xu, Xinyu Deng, Jose E. Alfáro, Li Chen, Dana Napier, Michael Lu,  Jian-An Huang, Chunming Liu, Olivier Thibault, Rosalind Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski*, Xiuwei H. Yang*. CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. Oncotarget. 2015 Oct 6;6(30):29675-93.

3. Yin Y, Deng X, Liu Z, Baldwin LA, Lefringhouse J, Zhang J, Hoff JT, Erfani SF, Rucker EB 3rd, O'Connor K, Liu C, Wu Y, Zhou BP, Yang XH*. CD151 represses mammary gland development by maintaining the niches of progenitor cells. Cell Cycle. 2014;13(17):2707-22.

4. Baldwin LA, Hoff JT, Lefringhouse J, Zhang M, Jia C, Liu Z, Erfani S, Jin H, Xu M, She QB, van Nagell JR, Wang C, Chen L, Plattner R, Kaetzel DM, Luo J, Lu M, West D, Liu C, Ueland FR, Drapkin R, Zhou BP, Yang X* CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. Oncotarget. 2014 Dec 15;5(23):12203-17.

5. Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang X*. CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. Oncotarget. 2015 Oct 6;6(30):29675-93.

6. Yang X*, Mirchev R, Deng X, Yacono P, Yang HL, Golan DE, Hemler ME. CD151 restricts the a6 integrin diffusion mode.J Cell Sci2012, 125:1478-87.

7. DengX, LiQ, Hoff JT, NovakM. Yang, HL, JinH, ErfaniSF, SharmaC,ZhouP, RabinovitzI, SonnenbergA, YiA, ZhouP, StippCS, KaetzelDM, HemlerME and Yang X*. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia2012, 14:678-689.

8. Yang

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   X, FloresL, Li Q, Zhou P, Xu F, Krop IE, and Hemler ME.Disruption OF Laminin-Integrin-CD151-FAK Axis Sensitizes Breast cancer Cells to ErbB2 Antagonists. Cancer Res2010, 70:2256-2263.

9. Yang X*,RichardsonAL, Torres-ArzayusM, ZhouP, SharmaC, Andzelm MM, StrongmingerJA, Brown Mand HemlerME. CD151 accelerates breast cancer progression by regulating 6 integrin function, signaling, and molecular organization. Cancer Res2008, 68:3204-3213.